| 1. Round | 05/02/2022 | Tauro FC | - | Sporting San Miguelito | 3:3 | ||||
| 6. Round | 08/03/2022 | UD Universitario | - | Sporting San Miguelito | 0:2 | ||||
| 8. Round | 19/03/2022 | Veraguas United | - | Sporting San Miguelito | 1:2 | ||||
| 13. Round | 23/04/2022 | Plaza Amador | - | Sporting San Miguelito | 1:1 | ||||
| 15. Round | 30/04/2022 | Sporting San Miguelito | - | Alianza | 1:0 |
Panama