| 18. Round | 27/02/2010 | Zakarpattya Uzhgorod | - | Metalurh Donetsk | 0:1 |  |
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| 19. Round | 07/03/2010 | Metalurh Donetsk | - | Shakhtar Donetsk | 0:1 | ||||
| 20. Round | 13/03/2010 | Metalurg Zaporizhya | - | Metalurh Donetsk | 3:2 | ||||
| 21. Round | 19/03/2010 | Metalurh Donetsk | - | Dinamo Kiev | 1:1 | ||||
| 23. Round | 03/04/2010 | Metalurh Donetsk | - | FK Krivbas (old) | 0:1 | ||||
| 13. Round | 07/04/2010 | Zorya Lugansk | - | Metalurh Donetsk | 1:1 | ||||
| 24. Round | 11/04/2010 | FK Illichivets | - | Metalurh Donetsk | 0:4 | ||||
| 25. Round | 15/04/2010 | Metalurh Donetsk | - | Vorskla Poltava | 1:3 | ||||
| 26. Round | 18/04/2010 | Chernomorets Odessa | - | Metalurh Donetsk | 1:1 | ||||
| 27. Round | 24/04/2010 | Metalist Kharkiv | - | Metalurh Donetsk | 2:0 | ||||
| 28. Round | 30/04/2010 | Metalurh Donetsk | - | Zorya Lugansk | 0:0 | ||||
| 29. Round | 05/05/2010 | Arsenal Kiev | - | Metalurh Donetsk | 2:0 | ||||
| 30. Round | 09/05/2010 | Metalurh Donetsk | - | FK Obolon | 5:0 | |
Bulgaria