| 1. Round | 19/11/2021 | ATK Mohun Bagan FC | - | Kerala Blasters | 4:2 | ||||
| 2. Round | 25/11/2021 | NorthEast United FC | - | Kerala Blasters | 0:0 | ||||
| 3. Round | 28/11/2021 | Bengaluru FC | - | Kerala Blasters | 1:1 | ||||
| 4. Round | 05/12/2021 | Kerala Blasters | - | Odisha FC | 2:1 | ||||
| 6. Round | 12/12/2021 | SC East Bengal | - | Kerala Blasters | 1:1 | ||||
| 7. Round | 19/12/2021 | Mumbai City FC | - | Kerala Blasters | 0:3 | ||||
| 10. Round | 02/01/2022 | Kerala Blasters | - | FC Goa | 2:2 | ||||
| 11. Round | 09/01/2022 | Kerala Blasters | - | Hyderabad FC | 1:0 | ||||
| 12. Round | 12/01/2022 | Odisha FC | - | Kerala Blasters | 0:2 | ||||
| 16. Round | 30/01/2022 | Kerala Blasters | - | Bengaluru FC | 0:1 | ||||
| 18. Round | 10/02/2022 | Jamshedpur FC | - | Kerala Blasters | 3:0 | ||||
| 21. Round | 14/02/2022 | Kerala Blasters | - | SC East Bengal | 1:0 | ||||
| 20. Round | 23/02/2022 | Hyderabad FC | - | Kerala Blasters | 2:1 | ||||
| 19. Round | 26/02/2022 | Kerala Blasters | - | Chennaiyin FC | 3:0 | ||||
| 13. Round | 02/03/2022 | Kerala Blasters | - | Mumbai City FC | 3:1 | ||||
| 22. Round | 06/03/2022 | FC Goa | - | Kerala Blasters | 4:4 |
Bhutan