| 7. Round | 02/10/2021 | Cardiff Metropolitan | - | Cefn Druids | 4:2 | ||||
| 9. Round | 12/10/2021 | Barry Town United | - | Cardiff Metropolitan | 0:1 | ||||
| 10. Round | 23/10/2021 | Cardiff Metropolitan | - | Connah's Quay Nomads | 1:1 | ||||
| 11. Round | 30/10/2021 | The New Saints | - | Cardiff Metropolitan | 5:0 |  |
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| 12. Round | 06/11/2021 | Cardiff Metropolitan | - | Caernarfon Town | 0:1 | |
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| 14. Round | 19/11/2021 | Cardiff Metropolitan | - | Aberystwyth Town | 0:1 | ||||
| 15. Round | 04/12/2021 | Cefn Druids | - | Cardiff Metropolitan | 1:3 | ||||
| 16. Round | 11/12/2021 | Connah's Quay Nomads | - | Cardiff Metropolitan | 0:0 | ||||
| 20. Round | 22/01/2022 | Cardiff Metropolitan | - | Bala Town | 0:0 | ||||
| 17. Round | 25/01/2022 | Cardiff Metropolitan | - | Barry Town United | 2:0 | ||||
| 21. Round | 29/01/2022 | Flint Town United | - | Cardiff Metropolitan | 2:2 | ||||
| 19. Round | 12/02/2022 | Cardiff Metropolitan | - | Newtown AFC | 1:1 | |
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| 18. Round | 19/02/2022 | Newtown AFC | - | Cardiff Metropolitan | 0:0 | |
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| 22. Round | 26/02/2022 | Cardiff Metropolitan | - | The New Saints | 1:1 |
Wales