| 1. Round | 17/08/2001 | FC Twente | - | RKC Waalwijk | 1:0 | ||||
| 2. Round | 21/08/2001 | NAC Breda | - | FC Twente | 3:3 | ||||
| 3. Round | 25/08/2001 | FC Twente | - | Roda JC Kerkrade | 3:0 |  |
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| 4. Round | 08/09/2001 | FC Twente | - | AFC Ajax | 0:2 | ||||
| 5. Round | 16/09/2001 | FC Groningen | - | FC Twente | 3:0 | ||||
| 7. Round | 30/09/2001 | Sparta Rotterdam | - | FC Twente | 1:1 | ||||
| 8. Round | 09/10/2001 | FC Twente | - | Willem II | 0:0 | ||||
| 9. Round | 14/10/2001 | De Graafschap | - | FC Twente | 4:2 | ||||
| 12. Round | 04/11/2001 | FC Utrecht | - | FC Twente | 1:1 |
Belgium