| 2. Round | 21/08/2021 | Birkirkara FC | - | Hamrun Spartans | 2:1 | ||||
| 4. Round | 19/09/2021 | Hamrun Spartans | - | Balzan FC | 0:1 | ||||
| 7. Round | 23/10/2021 | Gudja United | - | Hamrun Spartans | 1:3 | ||||
| 10. Round | 28/11/2021 | Hamrun Spartans | - | St. Luċija FC | 3:0 | ||||
| 11. Round | 05/12/2021 | Sliema Wanderers | - | Hamrun Spartans | 0:2 | ||||
| 17. Round | 05/02/2022 | Gżira United | - | Hamrun Spartans | 4:1 | ||||
| 18. Round | 13/02/2022 | Hamrun Spartans | - | Gudja United | 0:1 | ||||
| 20. Round | 26/02/2022 | Hamrun Spartans | - | Hibernians FC | 0:0 | ||||
| 22. Round | 11/03/2022 | Hamrun Spartans | - | Sliema Wanderers | 3:1 |
Malta