| 1. Round | 21/08/2022 | Valletta FC | - | Hibernians FC | 1:1 |  |
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| 2. Round | 26/08/2022 | Pietá Hotspurs | - | Valletta FC | 0:6 | ||||
| 3. Round | 03/09/2022 | Valletta FC | - | Sirens FC | 0:0 | ||||
| 4. Round | 10/09/2022 | Floriana FC | - | Valletta FC | 1:0 | |
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| 6. Round | 08/10/2022 | Valletta FC | - | Hamrun Spartans | 0:1 | ||||
| 7. Round | 15/10/2022 | Mosta FC | - | Valletta FC | 3:1 | ||||
| 8. Round | 22/10/2022 | Valletta FC | - | Gżira United | 0:0 | |
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| 9. Round | 29/10/2022 | Balzan FC | - | Valletta FC | 1:3 | ||||
| 11. Round | 12/11/2022 | St. Luċija FC | - | Valletta FC | 0:2 | ||||
| 12. Round | 04/12/2022 | Valletta FC | - | Gudja United | 0:1 | ||||
| 13. Round | 11/12/2022 | Marsaxlokk FC | - | Valletta FC | 1:2 | ||||
| 17. Round | 29/01/2023 | Valletta FC | - | Floriana FC | 0:0 | ||||
| 16. Round | 01/02/2023 | Sirens FC | - | Valletta FC | 3:3 | ||||
| 20. Round | 19/02/2023 | Valletta FC | - | Mosta FC | 0:0 | ||||
| 21. Round | 05/03/2023 | Gżira United | - | Valletta FC | 1:2 | ||||
| 23. Round | 01/04/2023 | Żebbuġ Rangers | - | Valletta FC | 1:5 | |
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| 25. Round | 14/04/2023 | Gudja United | - | Valletta FC | 1:2 |  |
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| 26. Round | 20/04/2023 | Valletta FC | - | Marsaxlokk FC | 1:1 |
Malta