| 1. Round | 25/04/2021 | New England Revolution | - | D.C. United | 1:0 | ||||
| 4. Round | 17/07/2021 | Atlanta United FC | - | New England Revolution | 0:1 | ||||
| 4. Round | 22/07/2021 | Inter Miami CF | - | New England Revolution | 0:5 | ||||
| 4. Round | 25/07/2021 | New England Revolution | - | CF Montréal | 2:1 |  |
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| 5. Round | 19/08/2021 | New England Revolution | - | D.C. United | 3:2 | ||||
| 5. Round | 22/08/2021 | New England Revolution | - | FC Cincinnati | 4:1 | ||||
| 5. Round | 29/08/2021 | New York City FC | - | New England Revolution | 2:0 | ||||
| 6. Round | 23/09/2021 | Chicago Fire | - | New England Revolution | 2:3 | ||||
| 7. Round | 25/10/2021 | Orlando City | - | New England Revolution | 2:2 |
Colombia