| 1. Round | 26/02/2022 | D.C. United | - | Charlotte FC | 3:0 | ||||
| 2. Round | 06/03/2022 | Charlotte FC | - | Los Angeles Galaxy | 0:1 | ||||
| 2. Round | 13/03/2022 | Atlanta United FC | - | Charlotte FC | 2:1 | ||||
| 2. Round | 19/03/2022 | Charlotte FC | - | New England Revolution | 3:1 | ||||
| 3. Round | 03/04/2022 | Philadelphia Union | - | Charlotte FC | 2:0 | ||||
| 3. Round | 17/04/2022 | New England Revolution | - | Charlotte FC | 2:1 |  |
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| 4. Round | 01/05/2022 | Orlando City | - | Charlotte FC | 2:1 | ||||
| 4. Round | 07/05/2022 | Charlotte FC | - | Inter Miami CF | 1:0 | ||||
| 4. Round | 15/05/2022 | Charlotte FC | - | CF Montréal | 0:2 | ||||
| 4. Round | 22/05/2022 | Charlotte FC | - | Vancouver Whitecaps | 2:1 | ||||
| 4. Round | 30/05/2022 | Seattle Sounders | - | Charlotte FC | 2:1 | ||||
| 6. Round | 10/07/2022 | Charlotte FC | - | Nashville SC | 4:1 | ||||
| 6. Round | 17/07/2022 | Inter Miami CF | - | Charlotte FC | 3:2 |
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