| 1. Round | 25/01/2022 | Deportes Quindío | - | Bogotá FC | 1:2 | ||||
| 2. Round | 31/01/2022 | Orsomarso SC | - | Deportes Quindío | 1:1 |  |
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| 3. Round | 06/02/2022 | Deportes Quindío | - | Llaneros FC | 0:0 | ||||
| 5. Round | 21/02/2022 | Boyacá Chicó | - | Deportes Quindío | 2:3 |  |
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| 6. Round | 28/02/2022 | Deportes Quindío | - | Boca Juniors de Cali | 1:0 | |
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| 7. Round | 07/03/2022 | Valledupar FC | - | Deportes Quindío | 0:0 | ||||
| 8. Round | 10/03/2022 | Deportes Quindío | - | Tigres FC | 0:0 | ||||
| 9. Round | 20/03/2022 | Fortaleza FC | - | Deportes Quindío | 2:2 | ||||
| 15. Round | 04/05/2022 | Leones FC | - | Deportes Quindío | 0:0 |
Colombia