| 1. Round | 19/07/2021 | Deportivo Pasto | - | Millonarios | 1:3 | ||||
| 2. Round | 22/07/2021 | Millonarios | - | Deportes Quindío | 2:1 | ||||
| 3. Round | 02/08/2021 | Once Caldas | - | Millonarios | 0:2 | ||||
| 4. Round | 08/08/2021 | Millonarios | - | Santa Fe | 0:1 | ||||
| 5. Round | 15/08/2021 | Deportivo Cali | - | Millonarios | 2:2 | ||||
| 10. Round | 19/09/2021 | Millonarios | - | Atlético Huila | 3:1 | ||||
| 11. Round | 26/09/2021 | Jaguares de Córdoba | - | Millonarios | 4:3 |
Colombia