| 4. Round | 15/08/2021 | Alianza | - | Luis Ángel Firpo | 2:2 | ||||
| 5. Round | 21/08/2021 | AD Chalatenango | - | Luis Ángel Firpo | 0:2 | ||||
| 7. Round | 29/08/2021 | FAS | - | Luis Ángel Firpo | 3:1 | ||||
| 9. Round | 15/09/2021 | Atlético Marte | - | Luis Ángel Firpo | 1:3 | ||||
| 11. Round | 26/09/2021 | CD Águila | - | Luis Ángel Firpo | 1:1 | ||||
| 12. Round | 02/10/2021 | Jocoro FC | - | Luis Ángel Firpo | 2:1 | ||||
| 14. Round | 09/10/2021 | Platense Zacatecoluca | - | Luis Ángel Firpo | 1:3 |  |
|||
| 13. Round | 17/10/2021 | Luis Ángel Firpo | - | Municipal Limeño | 1:1 | ||||
| 17. Round | 02/11/2021 | Once Municipal | - | Luis Ángel Firpo | 1:0 | ||||
| 20. Round | 18/11/2021 | Luis Ángel Firpo | - | Atlético Marte | 2:0 | ||||
| 21. Round | 21/11/2021 | Santa Tecla FC | - | Luis Ángel Firpo | 2:2 |
El Salvador