| 5. Round | 23/04/2021 | Galway United | - | UC Dublin | 2:2 | ||||
| 6. Round | 01/05/2021 | Cobh Ramblers | - | Galway United | 0:4 | ||||
| 7. Round | 07/05/2021 | Galway United | - | Bray Wanderers | 1:2 |  |
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| 10. Round | 28/05/2021 | Shelbourne FC | - | Galway United | 4:0 | ||||
| 11. Round | 11/06/2021 | Galway United | - | Athlone Town | 2:1 | ||||
| 12. Round | 18/06/2021 | Galway United | - | Cabinteely FC | 1:0 | ||||
| 13. Round | 25/06/2021 | Treaty United | - | Galway United | 0:1 | ||||
| 14. Round | 02/07/2021 | UC Dublin | - | Galway United | 0:2 | ||||
| 16. Round | 16/07/2021 | Bray Wanderers | - | Galway United | 0:0 | ||||
| 21. Round | 03/09/2021 | Cabinteely FC | - | Galway United | 0:1 | ||||
| 27. Round | 29/10/2021 | Cork City | - | Galway United | 3:0 |
Ireland