| 1. Round | 05/02/2022 | Sport Huancayo | - | Sporting Cristal | 1:0 | ||||
| 2. Round | 13/02/2022 | Sporting Cristal | - | FBC Melgar | 2:2 | ||||
| 4. Round | 25/02/2022 | Sporting Cristal | - | Universidad Técnica | 3:2 | ||||
| 5. Round | 06/03/2022 | Alianza Lima | - | Sporting Cristal | 0:1 | ||||
| 6. Round | 13/03/2022 | Sporting Cristal | - | Academia Cantolao | 2:2 | ||||
| 7. Round | 20/03/2022 | Carlos Stein | - | Sporting Cristal | 1:1 | ||||
| 11. Round | 23/04/2022 | Cienciano | - | Sporting Cristal | 0:1 | ||||
| 12. Round | 30/04/2022 | Sporting Cristal | - | Deportivo Binacional | 1:0 | ||||
| 13. Round | 08/05/2022 | AD Tarma | - | Sporting Cristal | 1:1 |  |
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| 14. Round | 13/05/2022 | Sporting Cristal | - | Ayacucho FC | 3:2 | |
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| 17. Round | 19/06/2022 | Atlético Grau | - | Sporting Cristal | 0:2 |  |
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| 18. Round | 25/06/2022 | Sporting Cristal | - | Alianza Atlético | 1:0 | ||||
| 19. Round | 03/07/2022 | Mannucci | - | Sporting Cristal | 1:3 |
Greece