| 1. Round | 07/08/2022 | NEC Nijmegen | - | FC Twente | 0:1 | ||||
| 2. Round | 14/08/2022 | FC Twente | - | Fortuna Sittard | 3:0 | ||||
| 4. Round | 28/08/2022 | FC Volendam | - | FC Twente | 1:0 | ||||
| 3. Round | 31/08/2022 | FC Twente | - | SBV Excelsior | 4:0 |  |
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| 5. Round | 03/09/2022 | FC Twente | - | PSV Eindhoven | 2:1 | ||||
| 6. Round | 11/09/2022 | AZ Alkmaar | - | FC Twente | 1:1 | ||||
| 8. Round | 01/10/2022 | FC Twente | - | Vitesse | 3:0 | ||||
| 9. Round | 09/10/2022 | Feyenoord | - | FC Twente | 2:0 | ||||
| 16. Round | 14/01/2023 | AFC Ajax | - | FC Twente | 0:0 |  |
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| 18. Round | 25/01/2023 | Vitesse | - | FC Twente | 2:2 |
Greece