| 1. Round | 28/08/2022 | APOEL Nikosia | - | Paphos FC | 1:1 |  |
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| 2. Round | 04/09/2022 | Anorthosis Famagusta | - | APOEL Nikosia | 0:2 | |
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| 3. Round | 10/09/2022 | APOEL Nikosia | - | Aris Limassol | 0:1 | ||||
| 4. Round | 17/09/2022 | Olympiakos Nikosia | - | APOEL Nikosia | 0:2 |  |
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| 10. Round | 04/11/2022 | APOEL Nikosia | - | Enosis Neon Paralimni | 2:0 | ||||
| 11. Round | 13/11/2022 | Doxa Katokopias | - | APOEL Nikosia | 0:1 | |
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| 12. Round | 27/11/2022 | APOEL Nikosia | - | Omonia Nikosia | 4:0 | |
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| 14. Round | 09/12/2022 | Paphos FC | - | APOEL Nikosia | 1:2 | ||||
| 15. Round | 17/12/2022 | APOEL Nikosia | - | Anorthosis Famagusta | 1:0 | ||||
| 16. Round | 22/12/2022 | Aris Limassol | - | APOEL Nikosia | 1:1 | ||||
| 20. Round | 22/01/2023 | APOEL Nikosia | - | Akritas Chlorakas | 2:0 | |
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| 22. Round | 03/02/2023 | APOEL Nikosia | - | Apollon Limassol | 3:1 | ||||
| 23. Round | 11/02/2023 | Enosis Neon Paralimni | - | APOEL Nikosia | 1:2 | ||||
| 24. Round | 19/02/2023 | APOEL Nikosia | - | Doxa Katokopias | 1:1 | ||||
| 25. Round | 25/02/2023 | Omonia Nikosia | - | APOEL Nikosia | 0:2 |
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