| 1. Round | 18/02/2022 | Dundalk FC | - | Derry City | 2:2 | ||||
| 3. Round | 28/02/2022 | Derry City | - | Sligo Rovers | 0:0 | ||||
| 9. Round | 09/04/2022 | Finn Harps | - | Derry City | 1:2 | ||||
| 12. Round | 22/04/2022 | Derry City | - | UC Dublin | 7:1 | ||||
| 13. Round | 29/04/2022 | St Patrick's Athletic | - | Derry City | 0:4 | ||||
| 17. Round | 23/05/2022 | Sligo Rovers | - | Derry City | 2:1 | ||||
| 20. Round | 17/06/2022 | Derry City | - | Drogheda United | 1:1 |  |
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| 21. Round | 24/06/2022 | UC Dublin | - | Derry City | 0:1 | ||||
| 22. Round | 01/07/2022 | Bohemian FC | - | Derry City | 2:3 | ||||
| 24. Round | 17/07/2022 | Finn Harps | - | Derry City | 1:2 | ||||
| 27. Round | 12/08/2022 | Derry City | - | Shamrock Rovers | 0:0 | ||||
| 28. Round | 19/08/2022 | Drogheda United | - | Derry City | 1:1 | ||||
| 19. Round | 29/08/2022 | Shelbourne FC | - | Derry City | 0:1 | ||||
| 29. Round | 02/09/2022 | Derry City | - | UC Dublin | 3:0 | ||||
| 30. Round | 09/09/2022 | Derry City | - | Bohemian FC | 1:0 | ||||
| 31. Round | 30/09/2022 | St Patrick's Athletic | - | Derry City | 0:1 | ||||
| 33. Round | 24/10/2022 | Sligo Rovers | - | Derry City | 0:0 | ||||
| 36. Round | 06/11/2022 | Derry City | - | Dundalk FC | 0:1 |
Ireland