| 1. Round | 22/08/2010 | 1. FSV Mainz 05 | - | VfB Stuttgart | 2:0 | ||||
| 2. Round | 29/08/2010 | VfB Stuttgart | - | Borussia Dortmund | 1:3 | ||||
| 4. Round | 18/09/2010 | VfB Stuttgart | - | Bor. Mönchengladbach | 7:0 |  |
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| 5. Round | 22/09/2010 | 1. FC Nürnberg | - | VfB Stuttgart | 2:1 | ||||
| 6. Round | 25/09/2010 | VfB Stuttgart | - | Bayer Leverkusen | 1:4 | ||||
| 7. Round | 03/10/2010 | VfB Stuttgart | - | Eintracht Frankfurt | 1:2 | ||||
| 8. Round | 16/10/2010 | FC Schalke 04 | - | VfB Stuttgart | 2:2 | ||||
| 9. Round | 24/10/2010 | VfB Stuttgart | - | FC St. Pauli | 2:0 | ||||
| 11. Round | 07/11/2010 | VfB Stuttgart | - | Werder Bremen | 6:0 | |
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| 12. Round | 13/11/2010 | 1. FC Kaiserslautern | - | VfB Stuttgart | 3:3 | ||||
| 13. Round | 21/11/2010 | VfB Stuttgart | - | 1. FC Köln | 0:1 | ||||
| 14. Round | 27/11/2010 | Hamburger SV | - | VfB Stuttgart | 4:2 | |
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| 20. Round | 30/01/2011 | VfB Stuttgart | - | SC Freiburg | 0:1 |
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