| 1. Round | 04/02/2022 | Universidad Técnica | - | Sport Boys | 2:1 | ||||
| 2. Round | 13/02/2022 | Sport Boys | - | Alianza Lima | 0:0 | ||||
| 7. Round | 19/03/2022 | Cienciano | - | Sport Boys | 4:1 |  |
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| 8. Round | 02/04/2022 | Sport Boys | - | Deportivo Binacional | 1:3 | ||||
| 13. Round | 07/05/2022 | Sport Boys | - | Atlético Grau | 2:1 | |
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| 14. Round | 15/05/2022 | Alianza Atlético | - | Sport Boys | 1:2 | ||||
| 15. Round | 22/05/2022 | Sport Boys | - | Mannucci | 1:4 | ||||
| 16. Round | 05/06/2022 | Sporting Cristal | - | Sport Boys | 3:0 | ||||
| 17. Round | 19/06/2022 | Sport Boys | - | FBC Melgar | 0:1 | ||||
| 19. Round | 03/07/2022 | Sport Boys | - | Sport Huancayo | 2:3 |
USA