| 1. Round | 11/08/2018 | Angers SCO | - | Nîmes Olympique | 3:4 |  |
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| 2. Round | 19/08/2018 | Nîmes Olympique | - | Olympique Marseille | 3:1 | ||||
| 3. Round | 25/08/2018 | Toulouse FC | - | Nîmes Olympique | 1:0 | ||||
| 4. Round | 01/09/2018 | Nîmes Olympique | - | Paris Saint-Germain | 2:4 | ||||
| 5. Round | 16/09/2018 | Girondins Bordeaux | - | Nîmes Olympique | 3:3 | ||||
| 6. Round | 21/09/2018 | AS Monaco | - | Nîmes Olympique | 1:1 | ||||
| 7. Round | 26/09/2018 | Nîmes Olympique | - | EA Guingamp | 0:0 | ||||
| 9. Round | 06/10/2018 | Nîmes Olympique | - | Stade de Reims | 0:0 | ||||
| 10. Round | 19/10/2018 | Olympique Lyonnais | - | Nîmes Olympique | 2:0 | ||||
| 11. Round | 26/10/2018 | Nîmes Olympique | - | AS Saint-Étienne | 1:1 | ||||
| 12. Round | 03/11/2018 | Dijon FCO | - | Nîmes Olympique | 0:4 | ||||
| 14. Round | 24/11/2018 | RC Strasbourg | - | Nîmes Olympique | 0:1 | ||||
| 15. Round | 01/12/2018 | Nîmes Olympique | - | Amiens SC | 3:0 | ||||
| 18. Round | 16/12/2018 | Nîmes Olympique | - | Lille OSC | 2:3 | |
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| 17. Round | 16/01/2019 | Nîmes Olympique | - | FC Nantes | 1:0 |  |
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| 21. Round | 19/01/2019 | Nîmes Olympique | - | Toulouse FC | 0:1 | ||||
| 20. Round | 23/01/2019 | Nîmes Olympique | - | Angers SCO | 3:1 | |
France