| 1. Round | 26/03/2021 | Galway United | - | Shelbourne FC | 0:0 | ||||
| 2. Round | 02/04/2021 | Athlone Town | - | Galway United | 3:1 | ||||
| 11. Round | 11/06/2021 | Galway United | - | Athlone Town | 2:1 | ||||
| 12. Round | 18/06/2021 | Galway United | - | Cabinteely FC | 1:0 | ||||
| 13. Round | 25/06/2021 | Treaty United | - | Galway United | 0:1 | ||||
| 14. Round | 02/07/2021 | UC Dublin | - | Galway United | 0:2 | ||||
| 15. Round | 09/07/2021 | Galway United | - | Cobh Ramblers | 2:0 | ||||
| 17. Round | 30/07/2021 | Wexford FC | - | Galway United | 1:3 | ||||
| 18. Round | 06/08/2021 | Galway United | - | Cork City | 2:3 | ||||
| 19. Round | 13/08/2021 | Galway United | - | Shelbourne FC | 3:1 | ||||
| 20. Round | 20/08/2021 | Athlone Town | - | Galway United | 1:0 | ||||
| 21. Round | 03/09/2021 | Cabinteely FC | - | Galway United | 0:1 |  |
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| 22. Round | 10/09/2021 | Galway United | - | Treaty United | 0:0 | ||||
| 23. Round | 24/09/2021 | Galway United | - | UC Dublin | 4:1 | ||||
| 24. Round | 01/10/2021 | Cobh Ramblers | - | Galway United | 0:1 | ||||
| 26. Round | 15/10/2021 | Galway United | - | Wexford FC | 2:1 |
Ireland