| Group G | 28/09/2011 | Shakhtar Donetsk | - | APOEL Nikosia | 1:1 | ||||
| Group G | 19/10/2011 | FC Porto | - | APOEL Nikosia | 1:1 | ||||
| Group G | 01/11/2011 | APOEL Nikosia | - | FC Porto | 2:1 |  |
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| Group G | 23/11/2011 | Zenit St. Petersburg | - | APOEL Nikosia | 0:0 | ||||
| Group G | 06/12/2011 | APOEL Nikosia | - | Shakhtar Donetsk | 0:2 | ||||
| Round of 16 | 14/02/2012 | Olympique Lyonnais | - | APOEL Nikosia | 1:0 | ||||
| Round of 16 | 07/03/2012 | APOEL Nikosia | - | Olympique Lyonnais | 4:3 pso | ||||
| Quarter-finals | 27/03/2012 | APOEL Nikosia | - | Real Madrid | 0:3 | ||||
| Quarter-finals | 04/04/2012 | Real Madrid | - | APOEL Nikosia | 5:2 |
Cyprus