| 2. Round | 20/08/2021 | Connah's Quay Nomads | - | Aberystwyth Town | 1:0 |  |
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| 3. Round | 28/08/2021 | Penybont FC | - | Connah's Quay Nomads | 1:1 |  |
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| 4. Round | 31/08/2021 | Connah's Quay Nomads | - | Caernarfon Town | 1:1 | |
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| 5. Round | 11/09/2021 | Barry Town United | - | Connah's Quay Nomads | 1:0 | ||||
| 6. Round | 18/09/2021 | Connah's Quay Nomads | - | Bala Town | 0:1 | ||||
| 8. Round | 09/10/2021 | Connah's Quay Nomads | - | The New Saints | 0:1 | ||||
| 11. Round | 29/10/2021 | Connah's Quay Nomads | - | Cefn Druids | 4:0 | |
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| 12. Round | 05/11/2021 | Bala Town | - | Connah's Quay Nomads | 0:4 | |
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| 14. Round | 20/11/2021 | Connah's Quay Nomads | - | Penybont FC | 0:0 | |
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| 15. Round | 03/12/2021 | Aberystwyth Town | - | Connah's Quay Nomads | 0:1 | ||||
| 16. Round | 11/12/2021 | Connah's Quay Nomads | - | Cardiff Metropolitan | 0:0 | |
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| 17. Round | 18/12/2021 | Connah's Quay Nomads | - | Haverfordwest County | 1:0 | ||||
| 20. Round | 21/01/2022 | The New Saints | - | Connah's Quay Nomads | 3:1 | ||||
| 19. Round | 11/02/2022 | Connah's Quay Nomads | - | Flint Town United | 2:0 | ||||
| 22. Round | 26/02/2022 | Newtown AFC | - | Connah's Quay Nomads | 0:2 | |
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England