| 1. Round | 15/05/2021 | Villa Española | - | Progreso | 0:0 |  |
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| 2. Round | 24/05/2021 | Sud América | - | Villa Española | 2:1 | ||||
| 3. Round | 29/05/2021 | Villa Española | - | Plaza Colonia | 1:3 | ||||
| 4. Round | 07/06/2021 | Fénix | - | Villa Española | 1:0 | ||||
| 5. Round | 14/06/2021 | Villa Española | - | Boston River | 2:2 | |
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| 6. Round | 19/06/2021 | Montevideo Wanderers | - | Villa Española | 3:0 | ||||
| 7. Round | 23/06/2021 | Villa Española | - | Rentistas | 0:1 | ||||
| 8. Round | 26/06/2021 | Peñarol | - | Villa Española | 1:1 | ||||
| 9. Round | 03/07/2021 | Villa Española | - | Montevideo City Torque | 2:3 | ||||
| 10. Round | 10/07/2021 | Villa Española | - | Deportivo Maldonado | 2:0 | ||||
| 11. Round | 25/07/2021 | Nacional | - | Villa Española | 3:0 | |
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| 12. Round | 02/08/2021 | Villa Española | - | Cerrito | 1:1 | ||||
| 15. Round | 22/08/2021 | Cerro Largo | - | Villa Española | 3:1 |
Uruguay