| 3. Round | 14/08/2021 | Marathón | - | Motagua | 2:0 | ||||
| 6. Round | 29/08/2021 | Marathón | - | Real España | 0:1 | ||||
| 7. Round | 04/09/2021 | Marathón | - | Real Sociedad | 2:1 | ||||
| 8. Round | 12/09/2021 | Victoria | - | Marathón | 1:0 | ||||
| 9. Round | 15/09/2021 | Marathón | - | Olimpia | 3:1 | ||||
| 15. Round | 24/10/2021 | Marathón | - | Platense | 1:1 |  |
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| 16. Round | 28/10/2021 | Olimpia | - | Marathón | 1:0 | ||||
| 17. Round | 30/10/2021 | Marathón | - | Victoria | 0:0 | ||||
| 18. Round | 10/11/2021 | Real Sociedad | - | Marathón | 0:3 | |
Honduras