| 1. Round | 26/06/2022 | Leones Negros | - | Alebrijes de Oaxaca | 0:0 | ||||
| 2. Round | 07/07/2022 | Alebrijes de Oaxaca | - | Venados FC | 0:0 | ||||
| 3. Round | 15/07/2022 | Pumas Tabasco | - | Alebrijes de Oaxaca | 0:2 |  |
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| 4. Round | 22/07/2022 | Alebrijes de Oaxaca | - | Cimarrones de Sonora | 1:1 | ||||
| 5. Round | 27/07/2022 | Correcaminos UAT | - | Alebrijes de Oaxaca | 0:0 | ||||
| 6. Round | 03/08/2022 | Alebrijes de Oaxaca | - | Tapatío | 4:0 | ||||
| 7. Round | 10/08/2022 | Alebrijes de Oaxaca | - | Mineros de Zacatecas | 2:2 | ||||
| 8. Round | 17/08/2022 | Cancún FC | - | Alebrijes de Oaxaca | 0:0 |  |
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| 9. Round | 26/08/2022 | Alebrijes de Oaxaca | - | Atlético Morelia | 1:3 | ||||
| 10. Round | 02/09/2022 | Tepatitlán | - | Alebrijes de Oaxaca | 1:1 | ||||
| 11. Round | 09/09/2022 | Alebrijes de Oaxaca | - | Alacranes de Durango | 4:0 | ||||
| 12. Round | 15/09/2022 | Alebrijes de Oaxaca | - | Atlante | 2:2 | |
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| 13. Round | 21/09/2022 | Club Celaya | - | Alebrijes de Oaxaca | 2:0 | |
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| 14. Round | 24/09/2022 | Alebrijes de Oaxaca | - | Coyotes de Tlaxcala | 3:0 | |
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| 15. Round | 30/09/2022 | Atlético La Paz | - | Alebrijes de Oaxaca | 2:1 |
Colombia