| 1. Round | 11/08/2000 | Independiente | - | Belgrano de Córdoba | 0:0 | ||||
| 3. Round | 19/08/2000 | Independiente | - | Huracán | 0:2 |  |
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| 5. Round | 05/09/2000 | Independiente | - | River Plate | 0:1 |  |
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| 6. Round | 09/09/2000 | Vélez Sarsfield | - | Independiente | 1:1 | ||||
| 7. Round | 16/09/2000 | Independiente | - | Colón de Santa Fe | 2:1 | ||||
| 8. Round | 22/09/2000 | Rosario Central | - | Independiente | 1:1 | ||||
| 10. Round | 12/10/2000 | Independiente | - | Talleres de Córdoba | 1:2 | ||||
| 12. Round | 28/10/2000 | Independiente | - | San Lorenzo | 1:2 | ||||
| 13. Round | 04/11/2000 | Chacarita Juniors | - | Independiente | 2:1 | |
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| 15. Round | 16/11/2000 | Argentinos Juniors | - | Independiente | 0:1 | ||||
| 16. Round | 25/11/2000 | Independiente | - | Unión de Santa Fe | 3:1 | ||||
| 17. Round | 01/12/2000 | Gimnasia de La Plata | - | Independiente | 3:2 |
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