1. Round | 09/07/2022 | Real Santander | - | Llaneros FC | 3:1 | ||||
2. Round | 17/07/2022 | Deportes Quindío | - | Real Santander | 2:0 | ||||
11. Round | 07/09/2022 | Real Santander | - | Valledupar FC | 1:0 | ||||
12. Round | 14/09/2022 | Barranquilla FC | - | Real Santander | 2:1 | ||||
14. Round | 23/09/2022 | Cúcuta Deportivo | - | Real Santander | 0:0 | ||||
15. Round | 03/10/2022 | Real Santander | - | Atlético Huila | 2:1 | ||||
16. Round | 08/10/2022 | Boca Juniors de Cali | - | Real Santander | 2:3 |