| 1. Round | 30/10/2021 | Portuguesa FC | - | Aragua FC | 1:1 |  |
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| 2. Round | 02/11/2021 | Metropolitanos FC | - | Portuguesa FC | 1:0 | ||||
| 4. Round | 09/11/2021 | Portuguesa FC | - | Academia Puerto Cabello | 2:0 | ||||
| 5. Round | 13/11/2021 | Hermanos Colmenarez | - | Portuguesa FC | 3:1 | ||||
| 6. Round | 18/11/2021 | Aragua FC | - | Portuguesa FC | 1:1 | |
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| 7. Round | 23/11/2021 | Portuguesa FC | - | Metropolitanos FC | 1:1 | ||||
| 9. Round | 30/11/2021 | Academia Puerto Cabello | - | Portuguesa FC | 0:0 | |
Venezuela