| 1. Round | 08/08/2021 | Honduras Progreso | - | Marathón | 1:2 | ||||
| 2. Round | 13/08/2021 | Platense | - | Honduras Progreso | 1:1 |  |
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| 3. Round | 15/08/2021 | Lobos UPNFM | - | Honduras Progreso | 3:0 | ||||
| 4. Round | 22/08/2021 | Honduras Progreso | - | Victoria | 2:0 |  |
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| 5. Round | 26/08/2021 | Olimpia | - | Honduras Progreso | 2:1 | |
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| 6. Round | 29/08/2021 | Honduras Progreso | - | Vida | 1:1 | ||||
| 7. Round | 05/09/2021 | Honduras Progreso | - | Motagua | 0:3 | ||||
| 8. Round | 12/09/2021 | Real Sociedad | - | Honduras Progreso | 1:0 | ||||
| 9. Round | 16/09/2021 | Honduras Progreso | - | Real España | 1:1 | |
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| 10. Round | 20/09/2021 | Vida | - | Honduras Progreso | 1:0 | ||||
| 11. Round | 23/09/2021 | Victoria | - | Honduras Progreso | 1:2 | ||||
| 12. Round | 03/10/2021 | Honduras Progreso | - | Platense | 4:2 | |
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| 13. Round | 09/10/2021 | Marathón | - | Honduras Progreso | 2:1 | ||||
| 14. Round | 17/10/2021 | Honduras Progreso | - | Lobos UPNFM | 0:1 | |
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| 15. Round | 24/10/2021 | Honduras Progreso | - | Olimpia | 0:2 | ||||
| 16. Round | 28/10/2021 | Real España | - | Honduras Progreso | 4:1 | |
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| 17. Round | 01/11/2021 | Honduras Progreso | - | Real Sociedad | 2:1 | |
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| 18. Round | 10/11/2021 | Motagua | - | Honduras Progreso | 3:2 | |
Honduras