| 1. Round | 18/01/2021 | Deportes Tolima | - | Once Caldas | 1:1 |  |
|||
| 6. Round | 15/02/2021 | Deportivo Pasto | - | Deportes Tolima | 0:1 | |
|||
| 9. Round | 25/02/2021 | Alianza Petrolera | - | Deportes Tolima | 0:5 | ||||
| 2. Round | 05/03/2021 | Santa Fe | - | Deportes Tolima | 3:2 | ||||
| 13. Round | 21/03/2021 | Deportivo Cali | - | Deportes Tolima | 0:0 | ||||
| 16. Round | 31/03/2021 | Deportes Tolima | - | Atlético Nacional | 2:1 | ||||
| 19. Round | 18/04/2021 | América de Cali | - | Deportes Tolima | 2:0 |
Colombia