| 1. Round | 11/07/2022 | Deportes Tolima | - | Independiente Medellín | 1:1 | ||||
| 2. Round | 15/07/2022 | Deportes Tolima | - | Deportivo Cali | 2:0 | ||||
| 3. Round | 19/07/2022 | Unión Magdalena | - | Deportes Tolima | 2:1 |  |
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| 5. Round | 02/08/2022 | Atlético Bucaramanga | - | Deportes Tolima | 2:1 | |
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| 7. Round | 13/08/2022 | Santa Fe | - | Deportes Tolima | 2:1 | |
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| 9. Round | 29/08/2022 | Atlético Junior | - | Deportes Tolima | 2:1 | ||||
| 10. Round | 04/09/2022 | Deportes Tolima | - | Cortuluá | 0:0 | ||||
| 11. Round | 10/09/2022 | Patriotas FC | - | Deportes Tolima | 1:1 | |
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| 12. Round | 17/09/2022 | Deportes Tolima | - | Once Caldas | 1:0 | ||||
| 13. Round | 22/09/2022 | América de Cali | - | Deportes Tolima | 0:0 | ||||
| 15. Round | 02/10/2022 | Águilas Doradas | - | Deportes Tolima | 1:2 | ||||
| 16. Round | 09/10/2022 | Deportivo Pasto | - | Deportes Tolima | 2:1 | |
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| 18. Round | 16/10/2022 | Cortuluá | - | Deportes Tolima | 0:1 | ||||
| 19. Round | 23/10/2022 | Deportes Tolima | - | Millonarios | 1:0 | |
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| 20. Round | 29/10/2022 | Envigado FC | - | Deportes Tolima | 1:1 |
Colombia