| 1. Round | 01/08/2010 | Cercle Brugge | - | Sporting Charleroi | 1:1 | ||||
| 2. Round | 07/08/2010 | Sporting Charleroi | - | RSC Anderlecht | 0:0 |  |
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| 3. Round | 15/08/2010 | KRC Genk | - | Sporting Charleroi | 5:0 | ||||
| 4. Round | 22/08/2010 | Sporting Charleroi | - | KAA Gent | 1:3 | ||||
| 5. Round | 28/08/2010 | Sporting Charleroi | - | KAS Eupen | 2:0 | ||||
| 6. Round | 11/09/2010 | Germinal Beerschot | - | Sporting Charleroi | 1:0 | ||||
| 7. Round | 19/09/2010 | Sporting Charleroi | - | Club Brugge KV | 0:5 | ||||
| 11. Round | 16/10/2010 | Sporting Charleroi | - | Sporting Lokeren | 1:2 | ||||
| 15. Round | 13/11/2010 | Sporting Charleroi | - | KVC Westerlo | 0:1 | ||||
| 16. Round | 20/11/2010 | Sporting Charleroi | - | KRC Genk | 1:3 | ||||
| 20. Round | 18/12/2010 | KAS Eupen | - | Sporting Charleroi | 1:0 | ||||
| 21. Round | 02/02/2011 | Sporting Charleroi | - | Germinal Beerschot | 2:0 | ||||
| 18. Round | 23/03/2011 | Sporting Charleroi | - | Cercle Brugge | 0:3 |
Belgium