| 18. Round | 31/01/2022 | KF Skënderbeu | - | KF Teuta Durrës | 0:1 | ||||
| 19. Round | 05/02/2022 | KF Tiranë | - | KF Skënderbeu | 3:2 | ||||
| 20. Round | 14/02/2022 | KF Skënderbeu | - | FK Partizani | 1:2 | ||||
| 21. Round | 19/02/2022 | Egnatia Rrogozhine | - | KF Skënderbeu | 2:0 |  |
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| 22. Round | 25/02/2022 | KF Skënderbeu | - | FK Vllaznia | 2:2 | ||||
| 23. Round | 03/03/2022 | KS Kastrioti | - | KF Skënderbeu | 1:0 | |
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| 24. Round | 08/03/2022 | KF Skënderbeu | - | Dinamo Tiranë | 0:1 | ||||
| 25. Round | 13/03/2022 | KF Laçi | - | KF Skënderbeu | 0:0 | ||||
| 26. Round | 20/03/2022 | KF Skënderbeu | - | FK Kukësi | 1:1 | ||||
| 27. Round | 03/04/2022 | KF Teuta Durrës | - | KF Skënderbeu | 0:0 | ||||
| 28. Round | 10/04/2022 | KF Skënderbeu | - | KF Tiranë | 0:4 | ||||
| 29. Round | 17/04/2022 | FK Partizani | - | KF Skënderbeu | 0:0 | ||||
| 30. Round | 24/04/2022 | KF Skënderbeu | - | Egnatia Rrogozhine | 0:1 | ||||
| 31. Round | 30/04/2022 | FK Vllaznia | - | KF Skënderbeu | 1:0 | ||||
| 32. Round | 04/05/2022 | KF Skënderbeu | - | KS Kastrioti | 2:0 | |
Albania