| 5. Round | 06/03/2011 | Danubio | - | Liverpool | 3:2 | ||||
| 6. Round | 13/03/2011 | River Plate | - | Danubio | 3:1 | ||||
| 7. Round | 20/03/2011 | Danubio | - | Montevideo Wanderers | 0:0 | ||||
| 8. Round | 02/04/2011 | Defensor Sporting | - | Danubio | 1:1 | ||||
| 9. Round | 09/04/2011 | Danubio | - | Peñarol | 0:1 | ||||
| 10. Round | 17/04/2011 | El Tanque Sisley | - | Danubio | 3:2 | ||||
| 11. Round | 24/04/2011 | Danubio | - | Tacuarembó | 3:1 |  |
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| 12. Round | 07/05/2011 | Racing | - | Danubio | 6:0 |
Colombia