1. Round | 24/07/2021 | MFK Ružomberok | - | FK Senica | 0:0 | ||||
4. Round | 13/08/2021 | AS Trenčín | - | MFK Ružomberok | 1:1 | ||||
5. Round | 21/08/2021 | MFK Ružomberok | - | Spartak Trnava | 0:0 | ||||
6. Round | 28/08/2021 | MFK Ružomberok | - | MFK Zemplín Michalovce | 0:0 | ||||
7. Round | 10/09/2021 | Zlaté Moravce | - | MFK Ružomberok | 2:2 | ||||
8. Round | 18/09/2021 | MFK Ružomberok | - | FC DAC 1904 | 1:2 | ||||
9. Round | 25/09/2021 | MŠK Žilina | - | MFK Ružomberok | 0:2 | ||||
10. Round | 02/10/2021 | MFK Ružomberok | - | Tatran Liptovský Mikuláš | 4:1 | ||||
11. Round | 16/10/2021 | FK Pohronie | - | MFK Ružomberok | 2:2 | ||||
12. Round | 23/10/2021 | FK Senica | - | MFK Ružomberok | 0:2 | ||||
13. Round | 30/10/2021 | MFK Ružomberok | - | ŠKF Sereď | 3:1 | ||||
14. Round | 07/11/2021 | Slovan Bratislava | - | MFK Ružomberok | 1:0 | ||||
15. Round | 19/11/2021 | MFK Ružomberok | - | AS Trenčín | 3:0 | ||||
16. Round | 28/11/2021 | Spartak Trnava | - | MFK Ružomberok | 0:3 | ||||
17. Round | 04/12/2021 | MFK Zemplín Michalovce | - | MFK Ružomberok | 0:3 | ||||
18. Round | 11/12/2021 | MFK Ružomberok | - | Zlaté Moravce | 1:1 |