| 1. Round | 24/01/2021 | Juventus Managua | - | ART Municipal Jalapa | 3:1 | ||||
| 4. Round | 05/02/2021 | Juventus Managua | - | Real Estelí FC | 0:1 | ||||
| 5. Round | 07/02/2021 | Juventus Managua | - | Managua FC | 0:5 | ||||
| 7. Round | 14/02/2021 | Juventus Managua | - | Chinandega | 1:3 | ||||
| 8. Round | 19/02/2021 | Real Madriz | - | Juventus Managua | 2:1 |  |
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| 13. Round | 23/04/2021 | Real Estelí FC | - | Juventus Managua | 4:0 |
Nicaragua