| 2. Round | 25/07/2021 | HNK Rijeka | - | NK Istra 1961 | 2:0 | ||||
| 3. Round | 31/07/2021 | NK Istra 1961 | - | HNK Gorica | 1:2 | ||||
| 5. Round | 14/08/2021 | Lokomotiva Zagreb | - | NK Istra 1961 | 4:0 |  |
|||
| 6. Round | 22/08/2021 | NK Istra 1961 | - | NK Osijek | 2:0 | ||||
| 7. Round | 28/08/2021 | HNK Šibenik | - | NK Istra 1961 | 3:1 | |
|||
| 8. Round | 12/09/2021 | NK Istra 1961 | - | Hajduk Split | 1:3 | |
|||
| 10. Round | 27/09/2021 | Hrvatski Dragovoljac | - | NK Istra 1961 | 0:1 | ||||
| 11. Round | 02/10/2021 | NK Istra 1961 | - | HNK Rijeka | 3:6 | ||||
| 18. Round | 06/12/2021 | NK Istra 1961 | - | Slaven Belupo | 1:2 | ||||
| 19. Round | 10/12/2021 | NK Istra 1961 | - | Hrvatski Dragovoljac | 3:0 | ||||
| 4. Round | 15/12/2021 | NK Istra 1961 | - | Dinamo Zagreb | 0:2 | ||||
| 20. Round | 18/12/2021 | HNK Rijeka | - | NK Istra 1961 | 1:0 |
Croatia