| 1. Round | 02/07/2022 | Mazatlán FC | - | Puebla FC | 2:4 | ||||
| 3. Round | 16/07/2022 | Puebla FC | - | Club León | 1:1 |  |
|||
| 6. Round | 31/07/2022 | Puebla FC | - | Atlético San Luis | 0:0 | ||||
| 16. Round | 03/08/2022 | Deportivo Toluca | - | Puebla FC | 1:1 | |
|||
| 9. Round | 17/08/2022 | Puebla FC | - | Club Necaxa | 2:2 | ||||
| 12. Round | 02/09/2022 | Gallos Blancos | - | Puebla FC | 1:1 | ||||
| 14. Round | 11/09/2022 | Deportivo Guadalajara | - | Puebla FC | 1:0 | ||||
| 15. Round | 17/09/2022 | Puebla FC | - | UANL Tigres | 2:1 |
Mexico