| 5. Round | 26/09/2021 | Marumo Gallants | - | Kaizer Chiefs | 0:0 | ||||
| 6. Round | 02/10/2021 | AmaZulu FC | - | Kaizer Chiefs | 1:1 | ||||
| 7. Round | 16/10/2021 | Kaizer Chiefs | - | Chippa United | 4:0 | ||||
| 8. Round | 24/10/2021 | SuperSport United | - | Kaizer Chiefs | 1:2 | ||||
| 9. Round | 02/11/2021 | Kaizer Chiefs | - | Stellenbosch FC | 0:1 | ||||
| 10. Round | 06/11/2021 | Kaizer Chiefs | - | Orlando Pirates | 2:1 | ||||
| 11. Round | 21/11/2021 | Maritzburg United | - | Kaizer Chiefs | 0:1 | ||||
| 19. Round | 24/11/2021 | Kaizer Chiefs | - | AmaZulu FC | 1:1 | ||||
| 12. Round | 28/11/2021 | Moroka Swallows | - | Kaizer Chiefs | 1:3 | ||||
| 15. Round | 12/12/2021 | Kaizer Chiefs | - | Sekhukhune United | 2:0 | ||||
| 16. Round | 19/12/2021 | Royal AM | - | Kaizer Chiefs | 1:0 | ||||
| 17. Round | 22/12/2021 | Kaizer Chiefs | - | Maritzburg United | 2:0 |
Nigeria