| 1. Round | 19/01/2020 | 12 de Octubre de Itauguá | - | Libertad | 0:3 | ||||
| 2. Round | 25/01/2020 | Libertad | - | Club Olimpia | 1:1 | ||||
| 3. Round | 02/02/2020 | Club Nacional | - | Libertad | 1:2 | ||||
| 4. Round | 07/02/2020 | Libertad | - | River Plate | 2:1 | ||||
| 5. Round | 14/02/2020 | Sportivo Luqueño | - | Libertad | 1:2 | ||||
| 7. Round | 28/02/2020 | Guaireña FC | - | Libertad | 3:2 | ||||
| 8. Round | 07/03/2020 | Libertad | - | General Díaz | 5:1 | ||||
| 9. Round | 21/07/2020 | Cerro Porteño | - | Libertad | 2:1 | ||||
| 10. Round | 25/07/2020 | San Lorenzo | - | Libertad | 1:2 | ||||
| 11. Round | 01/08/2020 | Libertad | - | Guaraní | 1:3 | ||||
| 12. Round | 08/08/2020 | Libertad | - | 12 de Octubre de Itauguá | 1:1 | ||||
| 13. Round | 13/08/2020 | Club Olimpia | - | Libertad | 2:1 |  |
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| 14. Round | 17/08/2020 | Libertad | - | Club Nacional | 2:0 | ||||
| 19. Round | 13/09/2020 | General Díaz | - | Libertad | 0:2 | ||||
| 20. Round | 21/09/2020 | Libertad | - | Cerro Porteño | 0:0 | |
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| 21. Round | 27/09/2020 | Libertad | - | San Lorenzo | 3:0 | ||||
| 22. Round | 04/10/2020 | Guaraní | - | Libertad | 1:1 |
Colombia