| 1. Round | 06/08/2005 | Standard Liège | - | Lierse SK (old) | 3:1 | ||||
| 3. Round | 20/08/2005 | KSK Beveren | - | Lierse SK (old) | 4:1 | ||||
| 4. Round | 27/08/2005 | Lierse SK (old) | - | Club Brugge KV | 1:1 | ||||
| 6. Round | 17/09/2005 | Lierse SK (old) | - | Sporting Charleroi | 0:0 | ||||
| 7. Round | 21/09/2005 | KVC Westerlo | - | Lierse SK (old) | 0:0 | ||||
| 8. Round | 25/09/2005 | Lierse SK (old) | - | RSC Anderlecht | 0:0 | ||||
| 9. Round | 01/10/2005 | KAA Gent | - | Lierse SK (old) | 1:1 | ||||
| 11. Round | 22/10/2005 | RAA La Louviére | - | Lierse SK (old) | 1:0 | ||||
| 5. Round | 09/11/2005 | Sporting Lokeren | - | Lierse SK (old) | 1:0 | ||||
| 16. Round | 03/12/2005 | Lierse SK (old) | - | FC Brussels | 1:1 |  |
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| 17. Round | 11/12/2005 | KSV Roeselare | - | Lierse SK (old) | 2:0 | ||||
| 15. Round | 14/12/2005 | Excelsior Mouscron | - | Lierse SK (old) | 5:0 | ||||
| 18. Round | 18/12/2005 | Lierse SK (old) | - | Standard Liège | 0:2 |
Colombia