| 1. Round | 01/08/2021 | Nueva Concepción | - | Achuapa | 0:0 |  |
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| 2. Round | 09/08/2021 | Comunicaciones | - | Nueva Concepción | 2:0 | ||||
| 4. Round | 15/08/2021 | Antigua GFC | - | Nueva Concepción | 4:0 | ||||
| 3. Round | 18/08/2021 | Nueva Concepción | - | Cobán Imperial | 2:1 | ||||
| 5. Round | 22/08/2021 | Nueva Concepción | - | Deportivo Guastatoya | 1:0 | ||||
| 6. Round | 25/08/2021 | Santa Lucía | - | Nueva Concepción | 2:1 | ||||
| 7. Round | 29/08/2021 | Nueva Concepción | - | CSD Municipal | 0:2 | ||||
| 8. Round | 04/09/2021 | Iztapa | - | Nueva Concepción | 2:0 |
Mexico