| 1. Round | 28/08/2021 | Linfield FC | - | Crusaders FC | 2:0 |  |
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| 2. Round | 31/08/2021 | Crusaders FC | - | Portadown FC | 4:0 | ||||
| 4. Round | 11/09/2021 | Crusaders FC | - | Cliftonville FC | 1:1 | ||||
| 5. Round | 18/09/2021 | Crusaders FC | - | Larne FC | 1:0 | |
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| 6. Round | 25/09/2021 | Glentoran FC | - | Crusaders FC | 0:3 | ||||
| 7. Round | 04/10/2021 | Crusaders FC | - | Coleraine FC | 0:2 | ||||
| 15. Round | 27/11/2021 | Ballymena United | - | Crusaders FC | 2:0 | |
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| 16. Round | 30/11/2021 | Crusaders FC | - | Portadown FC | 2:0 | ||||
| 21. Round | 01/01/2022 | Crusaders FC | - | Carrick Rangers | 0:0 | ||||
| 22. Round | 15/01/2022 | Warrenpoint Town | - | Crusaders FC | 0:1 | ||||
| 23. Round | 21/01/2022 | Crusaders FC | - | Glentoran FC | 1:2 | ||||
| 24. Round | 25/01/2022 | Portadown FC | - | Crusaders FC | 0:1 | ||||
| 25. Round | 29/01/2022 | Crusaders FC | - | Glenavon FC | 0:1 | ||||
| 27. Round | 12/02/2022 | Larne FC | - | Crusaders FC | 1:2 |  |
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| 10. Round | 15/02/2022 | Crusaders FC | - | Glenavon FC | 0:0 | ||||
| 33. Round | 26/03/2022 | Dungannon Swifts | - | Crusaders FC | 2:4 |
Northern Ireland