| 2. Round | 30/07/2010 | Oţelul Galaţi | - | Pandurii Târgu Jiu | 2:0 | ||||
| 3. Round | 08/08/2010 | Pandurii Târgu Jiu | - | Dinamo Bucureşti | 2:2 |  |
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| 4. Round | 13/08/2010 | Gloria Bistrița (old) | - | Pandurii Târgu Jiu | 3:0 | ||||
| 5. Round | 21/08/2010 | Pandurii Târgu Jiu | - | Gaz Metan Mediaş | 0:0 | ||||
| 6. Round | 28/08/2010 | CFR Cluj | - | Pandurii Târgu Jiu | 2:1 | ||||
| 7. Round | 13/09/2010 | Pandurii Târgu Jiu | - | FC Universitatea Craiova | 3:1 | |
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| 8. Round | 17/09/2010 | FC Victoria Brăneşti | - | Pandurii Târgu Jiu | 2:0 | ||||
| 9. Round | 26/09/2010 | Pandurii Târgu Jiu | - | FC Timişoara | 0:1 | ||||
| 10. Round | 01/10/2010 | Astra Ploieşti | - | Pandurii Târgu Jiu | 2:0 | ||||
| 11. Round | 16/10/2010 | Pandurii Târgu Jiu | - | Sportul Studenţesc | 1:0 | ||||
| 13. Round | 01/11/2010 | Rapid Bucureşti | - | Pandurii Târgu Jiu | 1:1 | ||||
| 14. Round | 06/11/2010 | Pandurii Târgu Jiu | - | FCM Târgu Mureş | 4:1 | ||||
| 15. Round | 13/11/2010 | Universitatea Cluj | - | Pandurii Târgu Jiu | 1:1 | ||||
| 16. Round | 19/11/2010 | Pandurii Târgu Jiu | - | FC Brașov | 2:1 | ||||
| 17. Round | 26/11/2010 | FC Vaslui | - | Pandurii Târgu Jiu | 3:1 |
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