1. Round | 01/08/2021 | CD Walter Ferretti | - | Real Madriz | 4:1 | ||||
2. Round | 08/08/2021 | Real Estelí FC | - | Real Madriz | 3:0 | ||||
5. Round | 29/08/2021 | Club Deportivo Ocotal | - | Real Madriz | 2:1 | ||||
6. Round | 02/09/2021 | Real Madriz | - | Diriangén FC | 0:1 | ![]() |
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9. Round | 26/09/2021 | Real Madriz | - | H&H Export Sébaco | 3:3 | ||||
12. Round | 18/10/2021 | Juventus Managua | - | Real Madriz | 1:0 | ||||
13. Round | 22/10/2021 | Real Madriz | - | UNAN Managua | 0:1 | ||||
14. Round | 25/10/2021 | Real Madriz | - | Club Deportivo Ocotal | 1:1 | ||||
15. Round | 01/11/2021 | ART Municipal Jalapa | - | Real Madriz | 0:1 | ||||
17. Round | 18/11/2021 | Real Madriz | - | Managua FC | 1:3 |