| 1. Round | 22/01/2022 | CD Walter Ferretti | - | Real Madriz | 3:0 | ||||
| 5. Round | 21/02/2022 | Club Deportivo Ocotal | - | Real Madriz | 2:0 | ||||
| 6. Round | 27/02/2022 | ART Municipal Jalapa | - | Real Madriz | 0:1 | ||||
| 7. Round | 03/03/2022 | Diriangén FC | - | Real Madriz | 3:0 | ||||
| 8. Round | 07/03/2022 | Real Madriz | - | Managua FC | 1:0 | ||||
| 9. Round | 09/03/2022 | H&H Export Sébaco | - | Real Madriz | 1:1 | ||||
| 10. Round | 14/03/2022 | Real Madriz | - | CD Walter Ferretti | 0:2 | ||||
| 11. Round | 20/03/2022 | Real Estelí FC | - | Real Madriz | 4:0 | ||||
| 14. Round | 10/04/2022 | Real Madriz | - | Club Deportivo Ocotal | 0:1 | ||||
| 16. Round | 25/04/2022 | Real Madriz | - | ART Municipal Jalapa | 3:0 dec. |
Nicaragua