| 1. Round | 23/02/2022 | Leones FC | - | Tigres FC | 1:1 |  |
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| 2. Round | 03/03/2022 | Atlético Huila | - | Tigres FC | 0:2 | ||||
| 2. Round | 16/03/2022 | Tigres FC | - | Atlético Huila | 2:0 | |
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| 3. Round | 30/03/2022 | Patriotas FC | - | Tigres FC | 0:0 | ||||
| 3. Round | 06/04/2022 | Tigres FC | - | Patriotas FC | 1:0 | ||||
| Round of 16 | 20/04/2022 | Independiente Medellín | - | Tigres FC | 1:0 | ||||
| Round of 16 | 11/05/2022 | Tigres FC | - | Independiente Medellín | 1:2 |
Colombia