| 13. Round | 06/11/2021 | Lille OSC | - | Angers SCO | 1:1 |  |
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| 14. Round | 21/11/2021 | Angers SCO | - | FC Lorient | 1:0 | ||||
| 15. Round | 26/11/2021 | RC Lens | - | Angers SCO | 2:2 | ||||
| 16. Round | 01/12/2021 | Angers SCO | - | AS Monaco | 1:3 | ||||
| 17. Round | 05/12/2021 | Stade de Reims | - | Angers SCO | 1:2 | ||||
| 18. Round | 12/12/2021 | Angers SCO | - | Clermont Foot 63 | 0:1 | ||||
| 21. Round | 16/01/2022 | FC Lorient | - | Angers SCO | 0:0 | ||||
| 22. Round | 23/01/2022 | Angers SCO | - | ESTAC Troyes | 2:1 | ||||
| 20. Round | 26/01/2022 | Angers SCO | - | AS Saint-Étienne | 0:1 | ||||
| 23. Round | 04/02/2022 | Olympique Marseille | - | Angers SCO | 5:2 | ||||
| 24. Round | 13/02/2022 | Angers SCO | - | RC Strasbourg | 0:1 | ||||
| 25. Round | 20/02/2022 | OGC Nice | - | Angers SCO | 1:0 | ||||
| 26. Round | 27/02/2022 | Angers SCO | - | RC Lens | 1:2 | ||||
| 27. Round | 06/03/2022 | Stade Rennais | - | Angers SCO | 2:0 | ||||
| 28. Round | 13/03/2022 | Angers SCO | - | Stade de Reims | 0:1 |
Montenegro