| 4. Round | 25/08/2020 | MFK Zemplín Michalovce | - | Zlaté Moravce | 1:0 | ||||
| 5. Round | 30/08/2020 | MŠK Žilina | - | MFK Zemplín Michalovce | 6:2 | ||||
| 6. Round | 12/09/2020 | MFK Zemplín Michalovce | - | AS Trenčín | 1:1 |  |
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| 7. Round | 19/09/2020 | MFK Ružomberok | - | MFK Zemplín Michalovce | 4:0 | ||||
| 8. Round | 26/09/2020 | MFK Zemplín Michalovce | - | FK Pohronie | 2:0 | ||||
| 9. Round | 03/10/2020 | ŠKF Sereď | - | MFK Zemplín Michalovce | 1:1 | ||||
| 10. Round | 17/10/2020 | MFK Zemplín Michalovce | - | FC DAC 1904 | 2:4 | ||||
| 12. Round | 31/10/2020 | Spartak Trnava | - | MFK Zemplín Michalovce | 1:2 | ||||
| 14. Round | 21/11/2020 | MFK Zemplín Michalovce | - | FK Senica | 0:1 | ||||
| 15. Round | 28/11/2020 | Zlaté Moravce | - | MFK Zemplín Michalovce | 0:0 | |
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| 17. Round | 13/12/2020 | AS Trenčín | - | MFK Zemplín Michalovce | 2:2 | ||||
| 18. Round | 16/12/2020 | MFK Zemplín Michalovce | - | MFK Ružomberok | 4:3 | |
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| 20. Round | 20/02/2021 | MFK Zemplín Michalovce | - | ŠKF Sereď | 0:2 | |
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| 21. Round | 27/02/2021 | FC DAC 1904 | - | MFK Zemplín Michalovce | 2:1 |
Cyprus
Serbia